Open AccessTotal Number of Alterations in Liquid Biopsies Is an Independent Predictor of Survival in Patients With Advanced Cancers
Author(s) -
Peter Vu,
Yulian Khagi,
Paul Riviere,
Aaron M. Goodman,
Razelle Kurzrock
Publication year - 2020
Publication title -
jco precision oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.405
H-Index - 22
ISSN - 2473-4284
DOI - 10.1200/po.19.00204
Subject(s) - medicine , hazard ratio , gastroenterology , multivariate analysis , proportional hazards model , oncology , liquid biopsy , circulating tumor dna , survival analysis , cancer , confidence interval
Studies have demonstrated an association between quantity of circulating tumor DNA (ctDNA) and poorer survival. We investigated the relationship between percent ctDNA (%ctDNA), total number of ctDNA alterations, and overall survival (OS) in liquid biopsies.
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