Open AccessHarmonization of Tumor Mutational Burden Quantification and Association With Response to Immune Checkpoint Blockade in Non–Small-Cell Lung Cancer
Author(s) -
Natalie I. Vokes,
David Liu,
Biagio Ricciuti,
E. Jimenez-Aguilar,
Hira Rizvi,
Felix Dietlein,
Meng He,
Claire A. Margolis,
Haitham Elmarakeby,
Jeffrey Girshman,
Anika E. Adeni,
Francisco Sánchez-Vega,
Nikolaus Schultz,
Suzanne E. Dahlberg,
Ahmet Zehir,
Pasi A. Jänne,
Mizuki Nishino,
Renato Umeton,
Lynette M. Sholl,
Eliezer M. Van Allen,
Matthew D. Hellmann,
Mark M. Awad
Publication year - 2019
Publication title -
jco precision oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.405
H-Index - 22
ISSN - 2473-4284
DOI - 10.1200/po.19.00171
Subject(s) - blockade , immune checkpoint , lung cancer , harmonization , immune system , cancer research , medicine , immunology , oncology , immunotherapy , receptor , physics , acoustics
Heterogeneity in tumor mutational burden (TMB) quantification across sequencing platforms limits the application and further study of this potential biomarker of response to immune checkpoint inhibitors (ICI). We hypothesized that harmonization of TMB across platforms would enable integration of distinct clinical datasets to better characterize the association between TMB and ICI response.