Open AccessIdentification and Confirmation of Potentially Actionable Germline Mutations in Tumor-Only Genomic Sequencing
Author(s) -
Donald W. Clark,
Kara N. Maxwell,
Jacquelyn Powers,
David Lieberman,
Jessica Ebrahimzadeh,
Jessica M. Long,
Danielle McKenna,
Payal D. Shah,
Angela R. Bradbury,
Jennifer J.D. Morrissette,
Katherine L. Nathanson,
Susan M. Domchek
Publication year - 2019
Publication title -
jco precision oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.405
H-Index - 22
ISSN - 2473-4284
DOI - 10.1200/po.19.00076
Subject(s) - germline , medicine , palb2 , referral , kras , germline mutation , msh6 , genetic testing , oncology , cancer , bioinformatics , genetics , gene , mutation , colorectal cancer , biology , family medicine , dna mismatch repair
Tumor-only genomic profiling (TGP) is increasingly advocated for all patients with cancer given the possible therapeutic implications. It is critical to develop clinical algorithms to identify and address potentially actionable germline findings identified by TGP.