Open AccessPediatric Somatic Tumor Sequencing Identifies Underlying Cancer Predisposition
Author(s) -
Suzanne P. MacFarland,
Kristin Zelley,
Lea F. Surrey,
Daniel Gallo,
Minjie Luo,
Pichai Raman,
Gerald Wertheim,
Stephen P. Hunger,
Marilyn M. Li,
Garrett M. Brodeur
Publication year - 2019
Publication title -
jco precision oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.405
H-Index - 22
ISSN - 2473-4284
DOI - 10.1200/po.19.00062
Subject(s) - somatic cell , biology , genetics , medicine , oncology , gene
The diagnosis of cancer predisposition in pediatric patients with cancer is vital for treatment decisions, surveillance, and management of at-risk family members. Somatic tumor testing can identify potential underlying constitutional variants that confer increased cancer risk. Here, we report the characteristics of constitutional variants identified through tumor testing.