Genomic Characterization of Prostatic Ductal Adenocarcinoma Identifies a High Prevalence of DNA Repair Gene Mutations | Zendy

Michael T. Schweizer | Zendy; Emmanuel S. Antonarakis | Zendy; Tarek A. Bismar | Zendy; Liana B. Guedes | Zendy; Heather H. Cheng | Zendy; Maria Tretiakova | Zendy; Funda VakarLopez | Zendy; Nola Klemfuss | Zendy; Eric Q. Konnick | Zendy; Elahe A. Mostaghel | Zendy; Andrew C. Hsieh | Zendy; Peter S. Nelson | Zendy; Evan Y. Yu | Zendy; Bruce Montgomery | Zendy; Lawrence D. True | Zendy; Jonathan I. Epstein | Zendy; Tamara L. Lotan | Zendy; Colin C. Pritchard | Zendy

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Genomic Characterization of Prostatic Ductal Adenocarcinoma Identifies a High Prevalence of DNA Repair Gene Mutations

Author(s) -

Michael T. Schweizer,

Emmanuel S. Antonarakis,

Tarek A. Bismar,

Liana B. Guedes,

Heather H. Cheng,

Maria Tretiakova,

Funda VakarLopez,

Nola Klemfuss,

Eric Q. Konnick,

Elahe A. Mostaghel,

Andrew C. Hsieh,

Peter S. Nelson,

Evan Y. Yu,

Bruce Montgomery,

Lawrence D. True,

Jonathan I. Epstein,

Tamara L. Lotan,

Colin C. Pritchard

Publication year - 2019

Publication title -

jco precision oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.405

H-Index - 22

ISSN - 2473-4284

DOI - 10.1200/po.18.00327

Subject(s) - dna repair , mutation , prostate cancer , cancer research , wnt signaling pathway , cancer , gene , biology , medicine , adenocarcinoma , dna sequencing , germline mutation , genetics

Ductal prostate cancer (dPC) is a rare variant of prostatic adenocarcinoma associated with poor outcomes. Although its histopathologic features are well characterized, the underlying molecular hallmarks of this aggressive subtype are not well described. We sought to provide a comprehensive overview of the spectrum of mutations associated with dPC.

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