Open AccessGenomic Characterization of Prostatic Ductal Adenocarcinoma Identifies a High Prevalence of DNA Repair Gene Mutations
Author(s) -
Michael T. Schweizer,
Emmanuel S. Antonarakis,
Tarek A. Bismar,
Liana B. Guedes,
Heather H. Cheng,
Maria Tretiakova,
Funda Vakar-López,
Nola Klemfuss,
Eric Q. Konnick,
Elahe A. Mostaghel,
Andrew C. Hsieh,
Peter S. Nelson,
Evan Y. Yu,
Robert B. Montgomery,
Lawrence D. True,
Jonathan I. Epstein,
Tamara L. Lotan,
Colin C. Pritchard
Publication year - 2019
Publication title -
jco precision oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.405
H-Index - 22
ISSN - 2473-4284
DOI - 10.1200/po.18.00327
Subject(s) - dna repair , mutation , prostate cancer , cancer research , wnt signaling pathway , cancer , gene , biology , medicine , adenocarcinoma , dna sequencing , germline mutation , genetics
Ductal prostate cancer (dPC) is a rare variant of prostatic adenocarcinoma associated with poor outcomes. Although its histopathologic features are well characterized, the underlying molecular hallmarks of this aggressive subtype are not well described. We sought to provide a comprehensive overview of the spectrum of mutations associated with dPC.