Role for Nucleotide Excision Repair Gene Variants in Oxaliplatin-Induced Peripheral Neuropathy | Zendy

Hannah D. West | Zendy; Michelle Coffey | Zendy; Michael J. Wagner | Zendy; Howard L. McLeod | Zendy; James Colley | Zendy; Richard Adams | Zendy; Oliver Fleck | Zendy; Tim Maughan | Zendy; David J. Fisher | Zendy; Richard Kaplan | Zendy; Rebecca Harris | Zendy; Jeremy P. Cheadle | Zendy

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Role for Nucleotide Excision Repair Gene Variants in Oxaliplatin-Induced Peripheral Neuropathy

Author(s) -

Hannah D. West,

Michelle Coffey,

Michael J. Wagner,

Howard L. McLeod,

James Colley,

Richard Adams,

Oliver Fleck,

Tim Maughan,

David J. Fisher,

Richard Kaplan,

Rebecca Harris,

Jeremy P. Cheadle

Publication year - 2018

Publication title -

jco precision oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.405

H-Index - 22

ISSN - 2473-4284

DOI - 10.1200/po.18.00090

Subject(s) - biology , nucleotide excision repair , dna repair , nonsynonymous substitution , ercc1 , oxaliplatin , exome , ercc2 , genetics , cancer research , exome sequencing , mutation , colorectal cancer , cancer , gene , genome

Oxaliplatin forms part of routine treatment of advanced colorectal cancer; however, it often causes severe peripheral neuropathy, resulting in treatment discontinuation. We sought to determine the molecular and cellular mechanism underlying this toxicity.

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