Repeated Abscopal Effect With Radiotherapy and Programmed Death 1 Blockade in Mismatch Repair–Deficient Endometrial Cancer | Zendy

Michael S. Oh | Zendy; Young Kwang Chae | Zendy

Open Access

Repeated Abscopal Effect With Radiotherapy and Programmed Death 1 Blockade in Mismatch Repair–Deficient Endometrial Cancer

Author(s) -

Michael S. Oh,

Young Kwang Chae

Publication year - 2018

Publication title -

jco precision oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.405

H-Index - 22

ISSN - 2473-4284

DOI - 10.1200/po.18.00085

Subject(s) - endometrial cancer , blockade , radiation therapy , medicine , abscopal effect , oncology , dna mismatch repair , cancer , immunotherapy , receptor , colorectal cancer

Radiotherapy for cancer has long been valued for its ability to target specific lesions to achieve tumor regression and improve patient symptoms. Though the effect of radiotherapy is typically limited to its targeted fields, reports have described response in distant tumors a phenomenon termed the abscopal effect.1 Prior studies have demonstrated that this effect may be mediated by an enhanced immune response against tumors,2 possibly elicited by tumorspecific antigens released by cancer cells exposed to radiation.3

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