Open AccessHES1 Protein Modulates Human Papillomavirus–Mediated Carcinoma of the Uterine Cervix
Author(s) -
Richa Tripathi,
Goutam Rath,
Vishwas Sharma,
Showket Hussain,
Shashi Sharma,
Mausumi Bharadwaj,
Ravi Mehrotra
Publication year - 2019
Publication title -
journal of global oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.002
H-Index - 17
ISSN - 2378-9506
DOI - 10.1200/jgo.18.00141
Subject(s) - medicine , human papillomavirus , uterine cervix , cervix , carcinoma , oncology , cancer research , gynecology , cancer
Cervical cancer (CC) is the most common cancer affecting women worldwide. Human papillomavirus (HPV) infection is a major contributing factor for the development of CC. The development of CC occurs progressively from precancer stages to cancerous stages (ie, invasive squamous cell carcinoma [ISCC] and adenocarcinoma [ADC]). ADC is a rare form of CC that develops from the mucinous endocervical epithelium. It is believed that the downstream targets of Notch signaling contribute to the etiology of CC. One such target is HES1, whose role in the modulation of ADC is unknown. The purpose of this study is to determine the role of HES1 protein in HPV-associated ADC subtype of CC and also to compare its expression in histologic subtypes of precancer and ISCC.