Open AccessReview of Haploidentical Hematopoietic Cell Transplantation
Author(s) -
Mehreen Ali Khan,
Qaiser Bashir,
Qamar Un Nisa Chaudhry,
Parvez Ahmed,
Tariq Mahmood Satti,
Syed Kamran Mahmood
Publication year - 2018
Publication title -
journal of global oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.002
H-Index - 17
ISSN - 2378-9506
DOI - 10.1200/jgo.18.00130
Subject(s) - medicine , hematopoietic cell , cyclophosphamide , transplantation , disease , hematopoietic stem cell transplantation , graft versus host disease , immune system , immunotherapy , oncology , immunology , haematopoiesis , intensive care medicine , chemotherapy , stem cell , genetics , biology
Use of haploidentical (haplo) donors for hematopoietic cell transplantation (HCT) has significantly increased in the last decade. The major advantage with this strategy is universal availability and faster acquisition of the donor, along with affordability and provision of immunotherapy in post-transplantation period. Historically, haplo-HCT was associated with compromised outcomes because of high rates of graft-versus-host disease and graft failure, but after the development of a post-transplantation high-dose cyclophosphamide strategy, which results in selective T-cell depletion, these issues have been addressed to a large extent. Nevertheless, graft failure, high treatment-related mortality due to graft-versus-host disease, infections, delayed immune reconstitution, and disease relapse remain significant concerns. As the experience with haplo-HCTs grows, the clinical outcomes are becoming more at par with those seen with fully matched unrelated donor allogeneic HCTs.