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Management of Stage III Non–Small-Cell Lung Cancer: ASCO Guideline
Author(s) -
Megan E. Daly,
Navneet Singh,
Nofisat Ismaila,
Mara B. Antonoff,
Douglas A. Arenberg,
Jeffrey D. Bradley,
Elizabeth A. David,
Frank C. Detterbeck,
Martin Früh,
Matthew A. Gubens,
Amy Moore,
Sukhmani K. Padda,
Jyoti D. Patel,
Tanyanika Phillips,
Angel Qin,
Clifford G. Robinson,
Charles B. Simone
Publication year - 2021
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.21.02528
Subject(s) - medicine , guideline , lung cancer , stage (stratigraphy) , oncology , randomized controlled trial , systematic review , evidence based medicine , radiation therapy , medline , intensive care medicine , alternative medicine , pathology , paleontology , political science , law , biology
PURPOSE To provide evidence-based recommendations to practicing clinicians on management of patients with stage III non–small-cell lung cancer (NSCLC).METHODS An Expert Panel of medical oncology, thoracic surgery, radiation oncology, pulmonary oncology, community oncology, research methodology, and advocacy experts was convened to conduct a literature search, which included systematic reviews, meta-analyses, and randomized controlled trials published from 1990 through 2021. Outcomes of interest included survival, disease-free or recurrence-free survival, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations.RESULTS The literature search identified 127 relevant studies to inform the evidence base for this guideline.RECOMMENDATIONS Evidence-based recommendations were developed to address evaluation and staging workup of patients with suspected stage III NSCLC, surgical management, neoadjuvant and adjuvant approaches, and management of patients with unresectable stage III NSCLC. Additional information is available at www.asco.org/thoracic-cancer-guidelines .

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