Open AccessImmune Therapy in GI Malignancies: A Review
Author(s) -
Judy Wang,
Kim A. Reiss,
Rina Khatri,
Elizabeth M. Jaffee,
Dan Laheru
Publication year - 2015
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.2015.60.7879
Subject(s) - immune system , medicine , immunotherapy , immune privilege , cancer , immunology , cancer immunotherapy , inflammation
The balance between tumor-promoting and tumor-suppressing immune responses and the difference between them ultimately determine whether a cancer escapes immune recognition mechanisms. Defining the complex relationships between the tumor itself, the tumor environment, and the immune system has been critical in facilitating the development of successful immunotherapies. This review explores the role of oncogenes in inducing cancer-associated inflammation, the local and systemic factors that lead to immune suppression, and immunotherapy approaches to overcome immune privilege.