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BRAF Mutation and CDKN2A Deletion Define a Clinically Distinct Subgroup of Childhood Secondary High-Grade Glioma
Author(s) -
Matthew Mistry,
Nataliya Zhukova,
Daniele Merico,
Patricia Rakopoulos,
Rahul Krishnatry,
Mary Shago,
James Stavropoulos,
Noa Alon,
Jason D. Pole,
Peter N. Ray,
Vilma Navickiene,
Joshua Mangerel,
Marc Remke,
Pawel Buczkowicz,
Vijay Ramaswamy,
Ana Guerreiro Stücklin,
Martin Li,
Edwin J. Young,
Cindy Zhang,
Pedro CasteloBranco,
Doua Bakry,
Suzanne Laughlin,
Adam Shlien,
Jennifer A. Chan,
Keith L. Ligon,
James T. Rutka,
Peter B. Dirks,
Michael D. Taylor,
Mark Greenberg,
David Malkin,
Annie Huang,
Éric Bouffet,
Cynthia Hawkins,
Uri Tabori
Publication year - 2015
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.2014.58.3922
Subject(s) - cdkn2a , medicine , glioma , v600e , oncology , cancer research , exome sequencing , mutation , biology , gene , genetics , cancer
To uncover the genetic events leading to transformation of pediatric low-grade glioma (PLGG) to secondary high-grade glioma (sHGG).

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