Fluorouracil Induces Myocardial Ischemia With Increases of Plasma Brain Natriuretic Peptide and Lactic Acid but Without Dysfunction of Left Ventricle | Zendy

Søren Astrup Jensen | Zendy; Philip Hasbak | Zendy; Jann Mortensen | Zendy; Jens Benn Sørensen | Zendy

Open Access

Fluorouracil Induces Myocardial Ischemia With Increases of Plasma Brain Natriuretic Peptide and Lactic Acid but Without Dysfunction of Left Ventricle

Author(s) -

Søren Astrup Jensen,

Philip Hasbak,

Jann Mortensen,

Jens Benn Sørensen

Publication year - 2010

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2009.27.3953

Subject(s) - medicine , folinic acid , radionuclide ventriculography , ejection fraction , cardiotoxicity , oxaliplatin , cardiology , ventricle , brain natriuretic peptide , natriuretic peptide , subclinical infection , fluorouracil , colorectal cancer , chemotherapy , heart failure , cancer

Fluorouracil (FU) is a cornerstone of colorectal cancer treatment; however, it has clinical and subclinical influence on the heart. This study aimed to clarify the pathophysiology, risk factors, and long-term effects of FU cardiotoxicity.

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