T-Cell–Depleted Reduced-Intensity Transplantation Followed by Donor Leukocyte Infusions to Promote Graft-Versus-Lymphoma Activity Results in Excellent Long-Term Survival in Patients With Multiply Relapsed Follicular Lymphoma | Zendy

Kirsty Thomson | Zendy; Emma Morris | Zendy; Don Milligan | Zendy; Anne Parker | Zendy; Ann E. Hunter | Zendy; Gordon Cook | Zendy; Adrian Bloor | Zendy; Fiona Clark | Zendy; Majid Kazmi | Zendy; David C. Linch | Zendy; Ronjon Chakraverty | Zendy; Karl S. Peggs | Zendy; Stephen Mackin | Zendy

Open Access

T-Cell–Depleted Reduced-Intensity Transplantation Followed by Donor Leukocyte Infusions to Promote Graft-Versus-Lymphoma Activity Results in Excellent Long-Term Survival in Patients With Multiply Relapsed Follicular Lymphoma

Author(s) -

Kirsty Thomson,

Emma Morris,

Don Milligan,

Anne Parker,

Ann E. Hunter,

Gordon Cook,

Adrian Bloor,

Fiona Clark,

Majid Kazmi,

David C. Linch,

Ronjon Chakraverty,

Karl S. Peggs,

Stephen Mackin

Publication year - 2010

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2009.26.9100

Subject(s) - medicine , alemtuzumab , fludarabine , transplantation , donor lymphocyte infusion , melphalan , surgery , follicular lymphoma , lymphoma , gastroenterology , graft versus host disease , chemotherapy , cyclophosphamide

Follicular lymphoma (FL) is an indolent disorder that is treatable but considered incurable with chemotherapy alone. The curative potential of allogeneic transplantation using conventional myeloablative conditioning has been demonstrated, but this approach is precluded in the majority of patients with FL because of excessive toxicity. Thus, reduced-intensity conditioning regimens are being explored.

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