SOX Antibodies in Small-Cell Lung Cancer and Lambert-Eaton Myasthenic Syndrome: Frequency and Relation With Survival | Zendy

Maarten J. Titulaer | Zendy; Rinse Klooster | Zendy; Marko Potman | Zendy; Lídia Sabater | Zendy; Francesc Graus | Zendy; Ingrid M. Hegeman | Zendy; Peter Thijssen | Zendy; Paul W. Wirtz | Zendy; A. Twijnstra | Zendy; Peter A.E. Sillevis Smitt | Zendy; Silvère M. van der Maarel | Zendy; Jan J.G.M. Verschuuren | Zendy

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SOX Antibodies in Small-Cell Lung Cancer and Lambert-Eaton Myasthenic Syndrome: Frequency and Relation With Survival

Author(s) -

Maarten J. Titulaer,

Rinse Klooster,

Marko Potman,

Lídia Sabater,

Francesc Graus,

Ingrid M. Hegeman,

Peter Thijssen,

Paul W. Wirtz,

A. Twijnstra,

Peter A.E. Sillevis Smitt,

Silvère M. van der Maarel,

Jan J.G.M. Verschuuren

Publication year - 2009

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2008.20.6169

Subject(s) - medicine , antibody , lambert eaton myasthenic syndrome , western blot , serology , paraneoplastic cerebellar degeneration , lung cancer , cancer , cerebellar degeneration , immunology , autoantibody , pathology , oncology , biology , biochemistry , gene , cerebellum

SOX1 antibodies are common in small-cell lung carcinoma (SCLC) with and without paraneoplastic syndrome (PNS) and can serve as serological tumor marker. Addition of other antibodies might improve its diagnostic power. We validated an enzyme-linked immunosorbent assay (ELISA) to assess the diagnostic value of serum antibodies in SCLC and Lambert-Eaton myasthenic syndrome (LEMS). Clinical outcome with respect to SOX antibodies was evaluated, as the SOX-related antitumor immune response might help to control the tumor growth.

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