Excellent Outcome With Reduced Treatment for Infants With Disseminated Neuroblastoma Without MYCN Gene Amplification | Zendy

Bruno De Bernardi | Zendy; Mary Gerrard | Zendy; Luca Boni | Zendy; Hervé Rubie | Zendy; Adela Cañete | Zendy; Andrea Di Cataldo | Zendy; Victoria Castel | Zendy; Ana Lacerda | Zendy; Ruth Ladenstein | Zendy; Ellen Ruud | Zendy; Bénédicte Brichard | Zendy; Jérôme Couturier | Zendy; Caroline Ellershaw | Zendy; Caroline Munzer | Zendy; Paolo Bruzzi | Zendy; Jean Michon | Zendy; Andrew D.J. Pearson | Zendy

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Excellent Outcome With Reduced Treatment for Infants With Disseminated Neuroblastoma Without MYCN Gene Amplification

Author(s) -

Bruno De Bernardi,

Mary Gerrard,

Luca Boni,

Hervé Rubie,

Adela Cañete,

Andrea Di Cataldo,

Victoria Castel,

Ana Lacerda,

Ruth Ladenstein,

Ellen Ruud,

Bénédicte Brichard,

Jérôme Couturier,

Caroline Ellershaw,

Caroline Munzer,

Paolo Bruzzi,

Jean Michon,

Andrew D.J. Pearson

Publication year - 2009

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2008.17.5877

Subject(s) - medicine , asymptomatic , neuroblastoma , chemotherapy , stage (stratigraphy) , concomitant , surgery , scintigraphy , lung , paleontology , genetics , biology , cell culture

On the assumption that most infants with disseminated neuroblastoma without MYCN amplification (MYCNA) have a favorable prognosis, two concomitant prospective trials were started in which chemotherapy was limited to patients presenting life- or organ-threatening symptoms or overt metastases to skeleton, lung, or CNS. Surgery was to be performed only in the absence of surgical risk factors.

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