Multicenter Study Using Paraffin-Embedded Tumor Tissue Testing PITX2 DNA Methylation As a Marker for Outcome Prediction in Tamoxifen-Treated, Node-Negative Breast Cancer Patients | Zendy

Nadia Harbeck | Zendy; Inko Nimmrich | Zendy; Arndt Hartmann | Zendy; Jeffrey S. Ross | Zendy; Tanja Čufer | Zendy; Robert Grützmann | Zendy; Glen Kristiansen | Zendy; Angelo Paradiso | Zendy; Oliver Hartmann | Zendy; Astrid Margossian | Zendy; John W.M. Martens | Zendy; Ina Schwope | Zendy; Antje Lukas | Zendy; Volkmar Müller | Zendy; Karin MildeLangosch | Zendy; Jörg Nährig | Zendy; John A. Foekens | Zendy; Sabine Maier | Zendy; Manfred Schmitt | Zendy; Ralf Lesche | Zendy

Open Access

Multicenter Study Using Paraffin-Embedded Tumor Tissue Testing PITX2 DNA Methylation As a Marker for Outcome Prediction in Tamoxifen-Treated, Node-Negative Breast Cancer Patients

Author(s) -

Nadia Harbeck,

Inko Nimmrich,

Arndt Hartmann,

Jeffrey S. Ross,

Tanja Čufer,

Robert Grützmann,

Glen Kristiansen,

Angelo Paradiso,

Oliver Hartmann,

Astrid Margossian,

John W.M. Martens,

Ina Schwope,

Antje Lukas,

Volkmar Müller,

Karin MildeLangosch,

Jörg Nährig,

John A. Foekens,

Sabine Maier,

Manfred Schmitt,

Ralf Lesche

Publication year - 2008

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2007.14.1697

Subject(s) - breast cancer , methylation , dna methylation , medicine , oncology , tamoxifen , cancer , hazard ratio , cancer research , biology , gene , gene expression , genetics , confidence interval

We recently reported DNA methylation of the paired-like homeodomain transcription factor 2 (PITX2) gene to be strongly correlated with increased risk of recurrence in node-negative, hormone receptor-positive, tamoxifen-treated breast cancer patients using fresh frozen specimens. Aims of the present study were to establish determination of PITX2 methylation for routine analysis in formalin-fixed paraffin-embedded (FFPE) breast cancer tissue and to test PITX2 DNA methylation as a biomarker for outcome prediction in an independent patient cohort.

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