Statins and the Risk of Colorectal Cancer: A Meta-Analysis of 18 Studies Involving More Than 1.5 Million Patients
Author(s) -
Stefanos Bonovas,
Kalitsa Filioussi,
Christodoulos Flordellis,
Nikolaos M. Sitaras
Publication year - 2007
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.2007.10.8936
Subject(s) - medicine , colorectal cancer , meta analysis , relative risk , publication bias , statin , randomized controlled trial , cohort study , oncology , random effects model , cancer , study heterogeneity , confidence interval
Statins have been suggested to prevent colorectal cancer. Several epidemiologic studies have evaluated this association, whereas randomized controlled trials (RCTs) on cardiovascular outcomes provide relevant data as a secondary end point. Our aim was to examine the strength of this association through a detailed meta-analysis of the studies published on the subject in peer-reviewed literature.
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