Platinum-Etoposide Chemotherapy in Elderly Patients With Small-Cell Lung Cancer: Results of a Randomized Multicenter Phase II Study Assessing Attenuated-Dose or Full-Dose With Lenograstim Prophylaxis—A Forza Operativa Nazionale Italiana Carcinoma Polmonare and Gruppo Studio Tumori Polmonari Veneto (FONICAP-GSTPV) Study | Zendy

Andrea Ardizzoni | Zendy; Adolfo Favaretto | Zendy; Luca Boni | Zendy; Editta Baldini | Zendy; Federico Castiglioni | Zendy; Paola Antonelli | Zendy; Franca Pari | Zendy; Carmelo Tibaldi | Zendy; A Altieri | Zendy; S. Barbera | Zendy; Giancarlo Cacciani | Zendy; M Raimondi | Zendy; Lucia Tixi | Zendy; Micaela Stefani | Zendy; S. Monfardini | Zendy; A Antilli | Zendy; Riccardo Rosso | Zendy; Adriano Paccagnella | Zendy

Open Access

Platinum-Etoposide Chemotherapy in Elderly Patients With Small-Cell Lung Cancer: Results of a Randomized Multicenter Phase II Study Assessing Attenuated-Dose or Full-Dose With Lenograstim Prophylaxis—A Forza Operativa Nazionale Italiana Carcinoma Polmonare and Gruppo Studio Tumori Polmonari Veneto (FONICAP-GSTPV) Study

Author(s) -

Andrea Ardizzoni,

Adolfo Favaretto,

Luca Boni,

Editta Baldini,

Federico Castiglioni,

Paola Antonelli,

Franca Pari,

Carmelo Tibaldi,

A Altieri,

S. Barbera,

Giancarlo Cacciani,

M Raimondi,

Lucia Tixi,

Micaela Stefani,

S. Monfardini,

A Antilli,

Riccardo Rosso,

Adriano Paccagnella

Publication year - 2005

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2005.11.140

Subject(s) - medicine , etoposide , regimen , chemotherapy , clinical endpoint , cisplatin , surgery , lung cancer , prophylactic cranial irradiation , phases of clinical research , gastroenterology , randomized controlled trial , conventional pci , myocardial infarction

Small-cell lung cancer (SCLC) is increasingly diagnosed in elderly patients, who are at higher risk of treatment-related morbidity and mortality. We conducted a randomized two-stage phase II study to assess the therapeutic index of two different platinum/etoposide regimens, attenuated-dose (AD) and full-dose (FD) plus prophylactic lenograstim.

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