Open AccessDevelopment and Validation of a Breast Cancer Risk Prediction Model for Childhood Cancer Survivors Treated With Chest Radiation: A Report From the Childhood Cancer Survivor Study and the Dutch Hodgkin Late Effects and LATER Cohorts
Author(s) -
Chaya S. Moskowitz,
Cécile M. Ronckers,
Joanne F. Chou,
Susan A. Smith,
Danielle Novetsky Friedman,
Dana Barnea,
Judith L. Kok,
Simone de Vries,
Suzanne L. Wolden,
Tara O. Henderson,
Helena J.H. van der Pal,
Leontien C. M. Kremer,
Joseph P. Neglia,
Lucie M. Turcotte,
Rebecca M. Howell,
Michael A. Arnold,
Michael Schaapveld,
Berthe M.P. Aleman,
Cécile P.M. Janus,
Birgitta Versluys,
Wendy Leisenring,
Charles A. Sklar,
Colin B. Begg,
Malcolm C. Pike,
Gregory T. Armstrong,
Leslie L. Robison,
Flora E. van Leeuwen,
Kevin C. Oeffinger
Publication year - 2021
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.20.02244
Subject(s) - medicine , childhood cancer , breast cancer , cancer , radiation therapy , oncology
Women treated with chest radiation for childhood cancer have one of the highest risks of breast cancer. Models producing personalized breast cancer risk estimates applicable to this population do not exist. We sought to develop and validate a breast cancer risk prediction model for childhood cancer survivors treated with chest radiation incorporating treatment-related factors, family history, and reproductive factors.