Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score | Zendy

Chi Gao | Zendy; Eric C. Polley | Zendy; Steven N. Hart | Zendy; Hongyan Huang | Zendy; Chunling Hu | Zendy; Rohan Gnanaolivu | Zendy; Jenna Lilyquist | Zendy; Nicholas J. Boddicker | Zendy; Jie Na | Zendy; Christine B. Ambrosone | Zendy; Paul L. Auer | Zendy; Leslie Bernstein | Zendy; Elizabeth S. Burnside | Zendy; A. Heather Eliassen | Zendy; Mia M. Gaudet | Zendy; Christopher A. Haiman | Zendy; David J. Hunter | Zendy; Eric J. Jacobs | Zendy; Esther M. John | Zendy; Sara Lindström | Zendy; Huiyan Ma | Zendy; Susan L. Neuhausen | Zendy; Polly A. Newcomb | Zendy; Katie M. O’Brien | Zendy; Janet E. Olson | Zendy; Irene M. Ong | Zendy; Alpa V. Patel | Zendy; Julie R. Palmer | Zendy; Dale P. Sandler | Zendy; Rulla M. Tamimi | Zendy; Jack A. Taylor | Zendy; Lauren R. Teras | Zendy; Amy TrenthamDietz | Zendy; Celine M. Vachon | Zendy; Clarice R. Weinberg | Zendy; Song Yao | Zendy; Jeffrey N. Weitzel | Zendy; David E. Goldgar | Zendy; Susan M. Domchek | Zendy; Katherine L. Nathanson | Zendy; Fergus J. Couch | Zendy; Peter Kraft | Zendy

Open Access

Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score

Author(s) -

Chi Gao,

Eric C. Polley,

Steven N. Hart,

Hongyan Huang,

Chunling Hu,

Rohan Gnanaolivu,

Jenna Lilyquist,

Nicholas J. Boddicker,

Jie Na,

Christine B. Ambrosone,

Paul L. Auer,

Leslie Bernstein,

Elizabeth S. Burnside,

A. Heather Eliassen,

Mia M. Gaudet,

Christopher A. Haiman,

David J. Hunter,

Eric J. Jacobs,

Esther M. John,

Sara Lindström,

Huiyan Ma,

Susan L. Neuhausen,

Polly A. Newcomb,

Katie M. O’Brien,

Janet E. Olson,

Irene M. Ong,

Alpa V. Patel,

Julie R. Palmer,

Dale P. Sandler,

Rulla M. Tamimi,

Jack A. Taylor,

Lauren R. Teras,

Amy TrenthamDietz,

Celine M. Vachon,

Clarice R. Weinberg,

Song Yao,

Jeffrey N. Weitzel,

David E. Goldgar,

Susan M. Domchek,

Katherine L. Nathanson,

Fergus J. Couch,

Peter Kraft

Publication year - 2021

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.20.01992

Subject(s) - breast cancer , medicine , genetic predisposition , polygenic risk score , oncology , cancer , population , gene , genetics , single nucleotide polymorphism , genotype , biology , disease , environmental health

This study assessed the joint association of pathogenic variants (PVs) in breast cancer (BC) predisposition genes and polygenic risk scores (PRS) with BC in the general population.

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