Open AccessRisk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score
Author(s) -
Chi Gao,
Eric C. Polley,
Steven N. Hart,
Hongyan Huang,
Chunling Hu,
Rohan Gnanaolivu,
Jenna Lilyquist,
Nicholas Boddicker,
Jie Na,
Christine B. Ambrosone,
Paul L. Auer,
Leslie Bernstein,
Elizabeth S. Burnside,
A. Heather Eliassen,
Mia M. Gaudet,
Christopher A. Haiman,
David J. Hunter,
Eric J. Jacobs,
Esther M. John,
Sara Lindström,
Hui Ma,
Susan L. Neuhausen,
Polly A. Newcomb,
Katie M. O’Brien,
Janet E. Olson,
Irene M. Ong,
Alpa V. Patel,
Julie R. Palmer,
Dale P. Sandler,
Rulla M. Tamimi,
Jack A. Taylor,
Lauren R. Teras,
Amy TrenthamDietz,
Celine M. Vachon,
Clarice R. Weinberg,
Song Yao,
Jeffrey N. Weitzel,
David E. Goldgar,
Susan M. Domchek,
Katherine L. Nathanson,
Fergus J. Couch,
Peter Kraft
Publication year - 2021
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.20.01992
Subject(s) - palb2 , chek2 , medicine , breast cancer , odds ratio , population , family history , oncology , genome wide association study , cancer , genetics , demography , genotype , single nucleotide polymorphism , biology , germline mutation , gene , mutation , environmental health , sociology
This study assessed the joint association of pathogenic variants (PVs) in breast cancer (BC) predisposition genes and polygenic risk scores (PRS) with BC in the general population.