Open AccessRisk of Prostate Cancer Associated With Familial and Hereditary Cancer Syndromes
Author(s) -
Jennifer L. BeebeDimmer,
Ashley L. Kapron,
Alison Fraser,
Ken R. Smith,
Kathleen A. Cooney
Publication year - 2020
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.19.02808
Subject(s) - medicine , family history , relative risk , cancer , population , prostate cancer , disease , oncology , poisson regression , gynecology , confidence interval , environmental health
Recently developed clinical guidelines suggest that men in families with specific cancer syndromes, such as hereditary breast and ovarian cancer (HBOC), consider genetic testing, especially in the setting of aggressive disease. However, although a family history (FH) of the same disease among close relatives is an established risk factor for prostate cancer (PC), a direct comparison of PC risk for men with each syndrome in a single population is needed.