Open AccessPathogenic Germline Mutations in DNA Repair Genes in Combination With Cancer Treatment Exposures and Risk of Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer
Author(s) -
Na Qin,
Zhaoming Wang,
Qi Liu,
Nan Song,
Carmen L. Wilson,
Matthew J. Ehrhardt,
Kyla Shelton,
John Easton,
Heather L. Mulder,
Dennis Kennetz,
Michael N. Edmonson,
Michael Rusch,
James R. Downing,
Melissa M. Hudson,
Kim E. Nichols,
Jinghui Zhang,
Leslie L. Robison,
Yutaka Yasui
Publication year - 2020
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.19.02760
Subject(s) - medicine , mutyh , dna repair , cancer , oncology , breast cancer , relative risk , germline mutation , gene , mutation , genetics , biology , confidence interval
To investigate cancer treatment plus pathogenic germline mutations (PGMs) in DNA repair genes (DRGs) for identification of childhood cancer survivors at increased risk of subsequent neoplasms (SNs).