Open AccessFactors Affecting Sentinel Node Metastasis in Thin (T1) Cutaneous Melanomas: Development and External Validation of a Predictive Nomogram
Author(s) -
Andrea Maurichi,
Rosalba Miceli,
Hanna Eriksson,
Julia Newton-Bishop,
Jérémie Nsengimana,
May P. Chan,
Andrew Hayes,
Kara Heelan,
David J. Adams,
Roberto Patuzzo,
Francesco Barretta,
Gianfrancesco Gallino,
Catherine A. Harwood,
Daniele Bergamaschi,
Dorothy C. Bennett,
Konstantinos Lasithiotakis,
Paola Ghiorzo,
Bruna Dalmasso,
Ausilia Maria Mangai,
Francesca Consoli,
Ilaria Mattavelli,
Consuelo Barbieri,
Andrea Leva,
Umberto Cortinovis,
Vittoria Espeli,
Cristina Mangas,
Pietro Quaglino,
Simone Ribero,
Paolo Broganelli,
Giovanni Pellacani,
Caterina Longo,
C. Del Forno,
Lorenzo Borgogi,
Serena Sestini,
Nicola Pimpinelli,
Sara Fortunato,
Alessandra Chiarugi,
Paolo Nardini,
Elena Morittu,
Antonio Florita,
Mara Cossa,
Barbara Valeri,
Massimo Milione,
Giancarlo Pruneri,
Odysseas Zoras,
Andrea Anichini,
Roberta Mortarini,
Mario Santinami
Publication year - 2020
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.19.01902
Subject(s) - nomogram , medicine , sentinel node , cohort , logistic regression , oncology , breslow thickness , recursive partitioning , lymphovascular invasion , melanoma , sentinel lymph node , metastasis , radiology , cancer , breast cancer , cancer research
Thin melanomas (T1; ≤ 1 mm) constitute 70% of newly diagnosed cutaneous melanomas. Regional node metastasis determined by sentinel node biopsy (SNB) is an important prognostic factor for T1 melanoma. However, current melanoma guidelines do not provide clear indications on when to perform SNB in T1 disease and stress an individualized approach to SNB that considers all clinicopathologic risk factors. We aimed to identify determinants of sentinel node (SN) status for incorporation into an externally validated nomogram to better select patients with T1 disease for SNB.