Clinical and Genetic Risk Prediction of Cognitive Impairment After Blood or Marrow Transplantation for Hematologic Malignancy | Zendy

Noha Sharafeldin | Zendy; Joshua Richman | Zendy; Alysia Bosworth | Zendy; Yanjun Chen | Zendy; Purnima Singh | Zendy; Sunita K. Patel | Zendy; Xuexia Wang | Zendy; Liton Francisco | Zendy; Stephen J. Forman | Zendy; F. Lennie Wong | Zendy; Smita Bhatia | Zendy

Open Access

Clinical and Genetic Risk Prediction of Cognitive Impairment After Blood or Marrow Transplantation for Hematologic Malignancy

Author(s) -

Noha Sharafeldin,

Joshua Richman,

Alysia Bosworth,

Yanjun Chen,

Purnima Singh,

Sunita K. Patel,

Xuexia Wang,

Liton Francisco,

Stephen J. Forman,

F. Lennie Wong,

Smita Bhatia

Publication year - 2020

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.19.01085

Subject(s) - medicine , hematologic malignancy , hematological malignancy , malignancy , transplantation , cognitive impairment , hematologic neoplasms , cognition , oncology , leukemia , bone marrow , bone marrow transplantation , immunology , disease , psychiatry

Using a candidate gene approach, we tested the hypothesis that individual single nucleotide polymorphisms (SNPs) and gene-level variants are associated with cognitive impairment in patients with hematologic malignancies treated with blood or marrow transplantation (BMT) and that inclusion of these SNPs improves risk prediction beyond that offered by clinical and demographic characteristics.

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