Open AccessClinical and Genetic Risk Prediction of Cognitive Impairment After Blood or Marrow Transplantation for Hematologic Malignancy
Author(s) -
Noha Sharafeldin,
Joshua Richman,
Alysia Bosworth,
Yanjun Chen,
Purnima Singh,
Sunita K. Patel,
Xuexia Wang,
Liton Francisco,
Stephen J. Forman,
F. Lennie Wong,
Smita Bhatia
Publication year - 2020
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.19.01085
Subject(s) - medicine , cohort , oncology , transplantation , single nucleotide polymorphism , gene , genetics , genotype , biology
Using a candidate gene approach, we tested the hypothesis that individual single nucleotide polymorphisms (SNPs) and gene-level variants are associated with cognitive impairment in patients with hematologic malignancies treated with blood or marrow transplantation (BMT) and that inclusion of these SNPs improves risk prediction beyond that offered by clinical and demographic characteristics.