Safety and Efficacy of T-DM1 Plus Neratinib in Patients With Metastatic HER2-Positive Breast Cancer: NSABP Foundation Trial FB-10 | Zendy

Jame Abraham | Zendy; A.J. Montero | Zendy; Rachel C. Jankowitz | Zendy; Mohamad A. Salkeni | Zendy; Jan H. Beumer | Zendy; Brian F. Kiesel | Zendy; Fanny Piette | Zendy; Laura M. Adamson | Zendy; Rebecca J. Nagy | Zendy; Richard B. Lanman | Zendy; Jeff Sperinde | Zendy; Weidong Huang | Zendy; Carmen J. Allegra | Zendy; Ashok Srinivasan | Zendy; Ying Wang | Zendy; Katherine L. PogueGeile | Zendy; Peter C. Lucas | Zendy; Samuel A. Jacobs | Zendy

Open Access

Safety and Efficacy of T-DM1 Plus Neratinib in Patients With Metastatic HER2-Positive Breast Cancer: NSABP Foundation Trial FB-10

Author(s) -

Jame Abraham,

A.J. Montero,

Rachel C. Jankowitz,

Mohamad A. Salkeni,

Jan H. Beumer,

Brian F. Kiesel,

Fanny Piette,

Laura M. Adamson,

Rebecca J. Nagy,

Richard B. Lanman,

Jeff Sperinde,

Weidong Huang,

Carmen J. Allegra,

Ashok Srinivasan,

Ying Wang,

Katherine L. PogueGeile,

Peter C. Lucas,

Samuel A. Jacobs

Publication year - 2019

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.19.00858

Subject(s) - neratinib , pertuzumab , medicine , metastatic breast cancer , tolerability , trastuzumab , oncology , nausea , breast cancer , gastroenterology , taxane , adverse effect , cancer

Patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer eventually develop resistance to dual-antibody therapy with trastuzumab plus pertuzumab. Mechanisms of resistance have not been well elucidated. We evaluated the safety, tolerability, and efficacy of ado-trastuzumab emtansine (T-DM1) plus neratinib in patients who progressed on trastuzumab plus pertuzumab.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research