Open AccessLesion-Level Response Dynamics to Programmed Cell Death Protein (PD-1) Blockade
Author(s) -
Juan C. Osorio,
Kathryn C. Arbour,
Dung T. Le,
Jennifer N. Durham,
Andrew J. Plodkowski,
Darragh Halpenny,
Michelle S. Ginsberg,
Peter Sawan,
Joseph G. Crompton,
Helena A. Yu,
Azadeh Namakydoust,
Barzin Y. Nabet,
Jamie E. Chaft,
Gregory J. Riely,
Hira Rizvi,
Luis A. Díaz,
Matthew D. Hellmann
Publication year - 2019
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.19.00709
Subject(s) - medicine , response evaluation criteria in solid tumors , lung cancer , oncology , immunotherapy , carcinoma , lesion , blockade , metastasis , cancer , pathology , progressive disease , chemotherapy , receptor
Response to programmed cell death protein 1 (PD-1) blockade is often conceptualized as resulting from reinvigoration of tumor-infiltrating lymphocytes. However, recruited antitumor immunity from the periphery may also be an important contributor to response. A detailed assessment of the response dynamics of individual metastasis could provide insight to the systemic and local features that mediate response and resistance to immunotherapy.