Lesion-Level Response Dynamics to Programmed Cell Death Protein (PD-1) Blockade | Zendy

Juan C. Osorio | Zendy; Kathryn C. Arbour | Zendy; Dung T. Le | Zendy; Jennifer N. Durham | Zendy; Andrew J. Plodkowski | Zendy; Darragh Halpenny | Zendy; Michelle S. Ginsberg | Zendy; Peter Sawan | Zendy; Joseph G. Crompton | Zendy; Helena A. Yu | Zendy; Azadeh Namakydoust | Zendy; Barzin Y. Nabet | Zendy; Jamie E. Chaft | Zendy; Gregory J. Riely | Zendy; Hira Rizvi | Zendy; Luis A. Díaz | Zendy; Matthew D. Hellmann | Zendy

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Lesion-Level Response Dynamics to Programmed Cell Death Protein (PD-1) Blockade

Author(s) -

Juan C. Osorio,

Kathryn C. Arbour,

Dung T. Le,

Jennifer N. Durham,

Andrew J. Plodkowski,

Darragh Halpenny,

Michelle S. Ginsberg,

Peter Sawan,

Joseph G. Crompton,

Helena A. Yu,

Azadeh Namakydoust,

Barzin Y. Nabet,

Jamie E. Chaft,

Gregory J. Riely,

Hira Rizvi,

Luis A. Díaz,

Matthew D. Hellmann

Publication year - 2019

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.19.00709

Subject(s) - blockade , medicine , lesion , programmed cell death , programmed cell death 1 , apoptosis , cell , cancer research , pd l1 , pathology , immune system , immunology , immunotherapy , receptor , biology , genetics

Response to programmed cell death protein 1 (PD-1) blockade is often conceptualized as resulting from reinvigoration of tumor-infiltrating lymphocytes. However, recruited antitumor immunity from the periphery may also be an important contributor to response. A detailed assessment of the response dynamics of individual metastasis could provide insight to the systemic and local features that mediate response and resistance to immunotherapy.

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