Open AccessPhase II Trial of Response-Based Radiation Therapy for Patients With Localized CNS Nongerminomatous Germ Cell Tumors: A Children's Oncology Group Study
Author(s) -
Jason Fangusaro,
Shengjie Wu,
S. MacDonald,
Erin S. Murphy,
Dennis Shaw,
Ute Bartels,
Soumen Khatua,
Mark M. Souweidane,
Hsiao Ming Lu,
David E. Morris,
Ashok Panigrahy,
Arzu OnarThomas,
Maryam Fouladi,
Amar Gajjar,
Girish Dhall
Publication year - 2019
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.19.00701
Subject(s) - medicine , germ cell tumors , radiation therapy , oncology , germ cell , radiation oncology , chemotherapy , biochemistry , chemistry , gene
Stratum 1 of ACNS1123 (ClinicalTrials.gov identifier: NCT01602666), a Children's Oncology Group phase II trial, evaluated efficacy of reduced-dose and volume of radiotherapy (RT) in children and adolescents with localized nongerminomatous germ cell tumors (NGGCTs). The primary objective was to evaluate the impact of reduced RT on progression-free survival (PFS) with a goal of preserving neurocognitive function.