Chromosomal Abnormalities and Prognosis in NPM1-Mutated Acute Myeloid Leukemia: A Pooled Analysis of Individual Patient Data From Nine International Cohorts | Zendy

Linus Angenendt | Zendy; Christoph Röllig | Zendy; Pau Montesinos | Zendy; David MartínezCuadrón | Zendy; Eva Barragán | Zendy; Raimundo García | Zendy; Carmen Botella | Zendy; Pilar Martı́nez | Zendy; Farhad Ravandi | Zendy; Tapan M. Kadia | Zendy; Hagop M. Kantarjian | Zendy; Jorge E. Cortés | Zendy; Gunnar Juliusson | Zendy; Vladimir Lazarević | Zendy; Martin Höglund | Zendy; Sören Lehmann | Zendy; Christian Récher | Zendy; Arnaud Pigneux | Zendy; Sarah Bertoli | Zendy; Pierre-Yves Dumas | Zendy; Hervé Dombret | Zendy; Claude Preudhomme | Zendy; JeanBaptiste Micol | Zendy; Christine Terré | Zendy; Zdeněk Ráčil | Zendy; Jan Novák | Zendy; Pavel Žák | Zendy; Andrew H. Wei | Zendy; Ing Soo Tiong | Zendy; Meaghan Wall | Zendy; Elihu H. Estey | Zendy; Carole Shaw | Zendy; Rita Exeler | Zendy; Lisa Wagenführ | Zendy; Friedrich Stölzel | Zendy; Christian Thiede | Zendy; Matthias Stelljes | Zendy; Georg Lenz | Zendy; Jan-Henrik Mikesch | Zendy; Hubert Serve | Zendy; Gerhard Ehninger | Zendy; Wolfgang E. Berdel | Zendy; Michael Krämer | Zendy; Utz Krug | Zendy; Christoph Schliemann | Zendy

Open Access

Chromosomal Abnormalities and Prognosis in NPM1-Mutated Acute Myeloid Leukemia: A Pooled Analysis of Individual Patient Data From Nine International Cohorts

Author(s) -

Linus Angenendt,

Christoph Röllig,

Pau Montesinos,

David MartínezCuadrón,

Eva Barragán,

Raimundo García,

Carmen Botella,

Pilar Martı́nez,

Farhad Ravandi,

Tapan M. Kadia,

Hagop M. Kantarjian,

Jorge E. Cortés,

Gunnar Juliusson,

Vladimir Lazarević,

Martin Höglund,

Sören Lehmann,

Christian Récher,

Arnaud Pigneux,

Sarah Bertoli,

Pierre-Yves Dumas,

Hervé Dombret,

Claude Preudhomme,

JeanBaptiste Micol,

Christine Terré,

Zdeněk Ráčil,

Jan Novák,

Pavel Žák,

Andrew H. Wei,

Ing Soo Tiong,

Meaghan Wall,

Elihu H. Estey,

Carole Shaw,

Rita Exeler,

Lisa Wagenführ,

Friedrich Stölzel,

Christian Thiede,

Matthias Stelljes,

Georg Lenz,

Jan-Henrik Mikesch,

Hubert Serve,

Gerhard Ehninger,

Wolfgang E. Berdel,

Michael Krämer,

Utz Krug,

Christoph Schliemann

Publication year - 2019

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.19.00416

Subject(s) - medicine , npm1 , myeloid leukemia , oncology , pooled analysis , myeloid , cancer research , karyotype , genetics , gene , chromosome , biology , meta analysis

Nucleophosmin 1 ( NPM1 ) mutations are associated with a favorable prognosis in acute myeloid leukemia (AML) when an internal tandem duplication (ITD) in the fms-related tyrosine kinase 3 gene ( FLT3 ) is absent ( FLT3 -ITD neg ) or present with a low allelic ratio ( FLT3 -ITD low ). The 2017 European LeukemiaNet guidelines assume this is true regardless of accompanying cytogenetic abnormalities. We investigated the validity of this assumption.

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