Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study | Zendy

KlausPeter Dieckmann | Zendy; Arlo Radtke | Zendy; Lajos Géczi | Zendy; Cord Matthies | Zendy; Petra Anheuser | Zendy; Ulrike Eckardt | Zendy; Jörg Sommer | Zendy; Friedemann Zengerling | Zendy; Emanuela Trenti | Zendy; Renate Pichler | Zendy; Hanjo Belz | Zendy; Stefan Zastrow | Zendy; Alexander Winter | Zendy; Sebastian Melchior | Zendy; Johannes Hammel | Zendy; Jennifer Kranz | Zendy; Marius Bolten | Zendy; S. Krege | Zendy; Björn Haben | Zendy; Wolfgang Loidl | Zendy; Christian Ruf | Zendy; Julia Heinzelbecker | Zendy; Axel Heidenreich | Zendy; Jann Frederik Cremers | Zendy; Christoph Oing | Zendy; Thomas Hermanns | Zendy; Christian D. Fankhauser | Zendy; Silke Gillessen | Zendy; Hermann Reichegger | Zendy; Richard Cathomas | Zendy; Martin Pichler | Zendy; Marcus Hentrich | Zendy; Klaus Eredics | Zendy; Anja Lorch | Zendy; Christian Wülfing | Zendy; Sven Peine | Zendy; Werner Wosniok | Zendy; Carsten Bokemeyer | Zendy; Gazanfer Belge | Zendy

Open Access

Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study

Author(s) -

KlausPeter Dieckmann,

Arlo Radtke,

Lajos Géczi,

Cord Matthies,

Petra Anheuser,

Ulrike Eckardt,

Jörg Sommer,

Friedemann Zengerling,

Emanuela Trenti,

Renate Pichler,

Hanjo Belz,

Stefan Zastrow,

Alexander Winter,

Sebastian Melchior,

Johannes Hammel,

Jennifer Kranz,

Marius Bolten,

S. Krege,

Björn Haben,

Wolfgang Loidl,

Christian Ruf,

Julia Heinzelbecker,

Axel Heidenreich,

Jann Frederik Cremers,

Christoph Oing,

Thomas Hermanns,

Christian D. Fankhauser,

Silke Gillessen,

Hermann Reichegger,

Richard Cathomas,

Martin Pichler,

Marcus Hentrich,

Klaus Eredics,

Anja Lorch,

Christian Wülfing,

Sven Peine,

Werner Wosniok,

Carsten Bokemeyer,

Gazanfer Belge

Publication year - 2019

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.18.01480

Subject(s) - seminoma , human chorionic gonadotropin , medicine , biomarker , orchiectomy , testicular cancer , germ cell tumors , population , stage (stratigraphy) , prospective cohort study , receiver operating characteristic , lactate dehydrogenase , oncology , pathology , gastroenterology , cancer , biology , hormone , chemotherapy , paleontology , biochemistry , environmental health , enzyme

Previous studies suggested that serum levels of microRNA (miR)-371a-3p (so-called M371 test) have a much higher sensitivity and specificity than the classic markers of testicular germ cell tumors (GCTs) and are applicable toward both seminoma and nonseminoma. We sought to confirm the usefulness of this test as a novel biomarker for GCT.

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