Integrating Genetic and Genomic Testing Into Oncology Practice | Zendy

Susan M. Domchek | Zendy; Elaine R. Mardis | Zendy; Jennifer W. Carlisle | Zendy; Taofeek K. Owonikoko | Zendy

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Integrating Genetic and Genomic Testing Into Oncology Practice

Author(s) -

Susan M. Domchek,

Elaine R. Mardis,

Jennifer W. Carlisle,

Taofeek K. Owonikoko

Publication year - 2020

Publication title -

american society of clinical oncology educational book

Language(s) - English

Resource type - Journals

eISSN - 1548-8756

pISSN - 1548-8748

DOI - 10.1200/edbk_280607

Subject(s) - germline , germline mutation , somatic cell , cancer , genetic testing , cancer genetics , hereditary cancer , medicine , biology , genetics , bioinformatics , oncology , mutation , gene , breast cancer

Genetic information, both germline and somatic, is an increasingly important consideration in therapeutic decision-making in cancer. Germline mutations in genes associated with increased cancer risk can identify those individuals without cancer who may benefit from enhanced screening and prevention strategies. In individuals with cancer, germline and somatic mutations may help to guide local and systemic management decisions. Here, we review considerations of these issues in selected cancer types.

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