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Integrated Computational Pipeline for Single-Cell Genomic Profiling
Author(s) -
Lubomir Chorbadjiev,
Jude Kendall,
Joan Alexander,
Viacheslav Zhygulin,
Junyan Song,
Michael Wigler,
Alexander Krasnitz
Publication year - 2020
Publication title -
jco clinical cancer informatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.188
H-Index - 12
ISSN - 2473-4276
DOI - 10.1200/cci.19.00171
Subject(s) - computer science , computational biology , python (programming language) , genomics , software , profiling (computer programming) , documentation , zoom , graphical user interface , genome browser , genome , pipeline (software) , visualization , biology , data mining , operating system , genetics , gene , paleontology , lens (geology)
Copy-number profiling of multiple individual cells from sparse sequencing may be used to reveal a detailed picture of genomic heterogeneity and clonal organization in a tissue biopsy specimen. We sought to provide a comprehensive computational pipeline for single-cell genomics, to facilitate adoption of this molecular technology for basic and translational research.

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