HLA-Arena: A Customizable Environment for the Structural Modeling and Analysis of Peptide-HLA Complexes for Cancer Immunotherapy | Zendy

Dinler A. Antunes | Zendy; Jayvee R. Abella | Zendy; Sarah Hall-Swan | Zendy; Didier Devaurs | Zendy; Anja Conev | Zendy; Mark Moll | Zendy; Gregory Lizée | Zendy; Lydia E. Kavraki | Zendy

Open Access

HLA-Arena: A Customizable Environment for the Structural Modeling and Analysis of Peptide-HLA Complexes for Cancer Immunotherapy

Author(s) -

Dinler A. Antunes,

Jayvee R. Abella,

Sarah Hall-Swan,

Didier Devaurs,

Anja Conev,

Mark Moll,

Gregory Lizée,

Lydia E. Kavraki

Publication year - 2020

Publication title -

jco clinical cancer informatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.188

H-Index - 12

ISSN - 2473-4276

DOI - 10.1200/cci.19.00123

Subject(s) - workflow , human leukocyte antigen , modeller , computational biology , computer science , peptide , cancer immunotherapy , structural bioinformatics , hla a , immunotherapy , protein structure , biology , homology modeling , antigen , immune system , database , immunology , biochemistry , enzyme

HLA protein receptors play a key role in cellular immunity. They bind intracellular peptides and display them for recognition by T-cell lymphocytes. Because T-cell activation is partially driven by structural features of these peptide-HLA complexes, their structural modeling and analysis are becoming central components of cancer immunotherapy projects. Unfortunately, this kind of analysis is limited by the small number of experimentally determined structures of peptide-HLA complexes. Overcoming this limitation requires developing novel computational methods to model and analyze peptide-HLA structures.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research