Open AccessEpigenetic Conservation Is a Beacon of Function: An Analysis Using Methcon5 Software for Studying Gene Methylation
Author(s) -
Emil Hvitfeldt,
Chao Xia,
Kimberly D. Siegmund,
Darryl Shibata,
Paul Marjoram
Publication year - 2020
Publication title -
jco clinical cancer informatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.188
H-Index - 12
ISSN - 2473-4276
DOI - 10.1200/cci.19.00109
Subject(s) - epigenetics , dna methylation , biology , gene , promoter , genetics , epigenetics of physical exercise , methylation , computational biology , conserved sequence , cpg site , gene expression , base sequence
Different epigenetic configurations allow one genome to develop into multiple cell types. Although the rules governing what epigenetic features confer gene expression are increasingly being understood, much remains uncertain. Here, we used a novel software package, Methcon5, to explore whether the principle of biologic conservation can be used to identify expressed genes. The hypothesis is that epigenetic configurations of important expressed genes will be conserved within a tissue.