Evidence-Based Network Approach to Recommending Targeted Cancer Therapies | Zendy

Jayaram Kancherla | Zendy; Shruti Rao | Zendy; Krithika Bhuvaneshwar | Zendy; Rebecca B. Riggins | Zendy; Robert A. Beckman | Zendy; Subha Madhavan | Zendy; Héctor Corrada Bravo | Zendy; Simina M. Boca | Zendy

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Evidence-Based Network Approach to Recommending Targeted Cancer Therapies

Author(s) -

Jayaram Kancherla,

Shruti Rao,

Krithika Bhuvaneshwar,

Rebecca B. Riggins,

Robert A. Beckman,

Subha Madhavan,

Héctor Corrada Bravo,

Simina M. Boca

Publication year - 2020

Publication title -

jco clinical cancer informatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.188

H-Index - 12

ISSN - 2473-4276

DOI - 10.1200/cci.19.00097

Subject(s) - drugbank , kegg , medicine , cancer , breast cancer , bioinformatics , informatics , context (archaeology) , targeted therapy , computational biology , biology , drug , pharmacology , gene , transcriptome , genetics , paleontology , gene expression , electrical engineering , engineering

In this work, we introduce CDGnet (Cancer-Drug-Gene Network), an evidence-based network approach for recommending targeted cancer therapies. CDGnet represents a user-friendly informatics tool that expands the range of targeted therapy options for patients with cancer who undergo molecular profiling by including the biologic context via pathway information.

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