Open AccessEvidence-Based Network Approach to Recommending Targeted Cancer Therapies
Author(s) -
Jayaram Kancherla,
Shruti Rao,
Krithika Bhuvaneshwar,
Rebecca B. Riggins,
Robert A. Beckman,
Subha Madhavan,
Héctor Corrada Bravo,
Simina M. Boca
Publication year - 2020
Publication title -
jco clinical cancer informatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.188
H-Index - 12
ISSN - 2473-4276
DOI - 10.1200/cci.19.00097
Subject(s) - drugbank , kegg , medicine , cancer , breast cancer , bioinformatics , informatics , context (archaeology) , targeted therapy , computational biology , biology , drug , pharmacology , gene , transcriptome , genetics , paleontology , gene expression , electrical engineering , engineering
In this work, we introduce CDGnet (Cancer-Drug-Gene Network), an evidence-based network approach for recommending targeted cancer therapies. CDGnet represents a user-friendly informatics tool that expands the range of targeted therapy options for patients with cancer who undergo molecular profiling by including the biologic context via pathway information.