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Insulitis in Human Type 1 Diabetes
Author(s) -
Hanafusa Toshiaki,
Imagawa Akihisa
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1447.052
Subject(s) - insulitis , fulminant , pancreatic islets , type 1 diabetes , immunology , major histocompatibility complex , immune system , islet , medicine , autoimmunity , biology , endocrinology , diabetes mellitus
Pancreatic tissues were analyzed immunohistologically in patients with autoimmune and fulminant type 1 diabetes (T1D) and control subjects. Both β and alpha cells were decreased in fulminant T1D, but only β cells were significantly decreased in autoimmune T1D. Insulitis was seen in both subtypes of T1D, but it remained longer in autoimmune than in fulminant T1D. Lymphocytic infiltration to the exocrine pancreatic tissue was observed only in fulminant T1D, whereas immunologically abnormal findings, such as increased expression of MHC class I molecule and Fas antigen in islet cells and Fas‐ligand expression in infiltrating lymphocytes, were detected only in autoimmune T1D. From these findings, together with clinical features, it could be concluded that in autoimmune T1D, β cells are assumed to be destroyed through a long‐standing autoimmune process, whereas in fulminant T1D, β cells seem to be destroyed very rapidly, probably by a destructive process triggered by viral infection.