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Tumor Necrosis Factor Alpha Inducing Spatial Interactions between Calcium‐Sensing Receptor and L‐Type Voltage‐Dependent Calcium Channel
Author(s) -
Parkash Jai
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1447.030
Subject(s) - calcium , calcium channel , microbiology and biotechnology , tumor necrosis factor alpha , voltage dependent calcium channel , chemistry , calcium sensing receptor , calcium signaling , calcium in biology , receptor , calcium metabolism , t type calcium channel , biology , endocrinology , intracellular , biochemistry , organic chemistry
The temporal and spatial regulation of intracellular calcium concentration ([Ca 2+ ] i ) is very crucial for maintaining calcium ion homeostasis within cells, and consequently in the regulation of cellular functions such as β cell replication and differentiation, insulin secretion, and apoptosis. Calcium ion regulatory proteins playing major roles in these processes include L‐type voltage‐dependent calcium channels (L‐type VDCCs) and calcium‐sensing receptors (CaRs). Tumor necrosis factor alpha (TNF‐α), a cytokine, is widely known to activate nuclear factor‐kappa B (NF‐κB) transcription in β cells. Confocal fluorescence imaging data suggest increased co‐localization of CaRs with L‐type VDCCs upon treatment of β cells with TNF‐α, thereby indicating increased membrane‐delimited spatial interactions between these two membrane proteins.