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Closing the Circle between the Bedside and the Bench
Author(s) -
Bortell Rita,
Pino Steven C.,
Greiner Dale L.,
Zipris Danny,
Rossini Aldo A.
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1447.025
Subject(s) - bench to bedside , innate immune system , diabetes mellitus , type 1 diabetes , immunity , immunology , biology , mechanism (biology) , biomedicine , bioinformatics , computational biology , medicine , neuroscience , immune system , medical physics , endocrinology , philosophy , epistemology
Animal models provide many strategies to unravel the complex interplay of genetic, immunologic, and environmental factors involved in the pathogenesis of type 1A (autoimmune) diabetes. Diabetes can be studied at multiple levels, and new technological advancements provide insights into the functioning of organelle and cellular structures. The role of innate immunity in the response to environmental pathogens has provided possible biochemical and molecular mechanisms which can explain certain clinical events in diabetes. These investigations may uncover new therapies and strategies to prevent type 1A diabetes.