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Congenic Mapping of the MHC‐Linked Susceptibility to Type 1 Diabetes in the NOD Mouse
Author(s) -
Hiromine Yoshihisa,
Fujisawa Tomomi,
Noso Shinsuke,
Babaya Naru,
Kawabata Yumiko,
Ikegami Hiroshi
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1447.019
Subject(s) - congenic , major histocompatibility complex , biology , genetics , phenotype , strain (injury) , nod , gene , anatomy
Major histocompatibility complex (MHC)‐linked susceptibility to type 1 diabetes consists of multiple components. Previous studies with NOD mice congenic for the MHC from a sister strain, the CTS mouse, mapped Idd16 , a second component of MHC‐linked susceptibility to type 1 diabetes, in the region adjacent to, but distinct from Idd1 in the class II region. In this study, three lines of subcongenic strains were established from the original congenic strain. Phenotypic analysis of the strains indicated that MHC‐linked susceptibility to type 1 diabetes consists of at least three components: Idd1 , Idd16.2 adjacent to Idd1, and Idd16.1 telomeric to Idd16.2 .