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Maillard Products as Biomarkers in Cancer
Author(s) -
Bachmeier Beatrice E.,
Nerlich Andreas G.,
Rohrbach Helmut,
Schleicher Erwin D.,
Friess Ulrich
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1433.057
Subject(s) - staining , breast cancer , pathology , cancer research , cancer , breast carcinoma , cancer cell , lysine , chemistry , biology , medicine , biochemistry , amino acid
Because tumors exert increased glycolysis rates, a high intracellular carbonyl stress with the formation of Maillard products may evolve. Therefore, we studied the presence of N ɛ ‐(carboxymethyl)lysine (CML) modification in breast cancer tissues from 20 patients and found significant cytoplasmatic staining in tumor cells that was independent of the tumor stage, tumor type, and microanatomic localization. Studying breast cancer cell lines, we also found strong cytoplasmatic CML staining that was again independent of their invasive or metastatic behavior. Our results reveal that tumor cells show a strong cytoplasmatic immunoreactivity to CML without evident association with breast carcinoma type, differentiation, tumor stage, or intratumoral localization. We conclude that CML formation is a general tumor cell‐associated process.