Premium
Dicarbonyls Stimulate Cellular Protection Systems in Primary Rat Hepatocytes and Show Anti‐inflammatory Properties
Author(s) -
Buetler Timo M.,
Latado Hélia,
Baumeyer Alexandra,
Delatour Thierry
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1433.036
Subject(s) - detoxification (alternative medicine) , chemistry , primary (astronomy) , antioxidant , tumor necrosis factor alpha , microbiology and biotechnology , glycation , oxidative stress , pharmacology , biochemistry , cancer research , receptor , biology , immunology , medicine , physics , alternative medicine , pathology , astronomy
Advanced glycation endproducts (AGEs) and their precursor dicarbonyls are generally perceived as having adverse health effects. They are also considered to be initiators and promoters of disease and aging. However, proof for a causal relationship is lacking. On the other hand, it is known that AGEs and melanoidins possess beneficial properties, such as antioxidant and metal‐chelating activities. Furthermore, some AGEs may stimulate the cellular detoxification system, generally known as the phase II drug metabolizing system. We show here that several reactive dicarbonyl intermediates have the capability to stimulate the cellular phase II detoxification systems in both a reporter cell line and primary rat hepatocytes. In addition, we demonstrate that dicarbonyls can attenuate the inflammatory signaling induced by tumor necrosis factor‐α in a reporter cell system.