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Oxidative Stress and Advanced Glycation in Diabetic Nephropathy
Author(s) -
Coughlan Melinda T.,
Mibus Amy L.,
Forbes Josephine M.
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1433.018
Subject(s) - glycation , rage (emotion) , oxidative stress , diabetic nephropathy , reactive oxygen species , diabetes mellitus , advanced glycation end product , medicine , nephropathy , population , endocrinology , bioinformatics , chemistry , biology , biochemistry , neuroscience , environmental health
Nephropathy remains a significant cause of morbidity and mortality in the diabetic population and is the leading cause of end‐stage renal failure in the Western World. As a result of the diabetic milieu, increased generation of reactive oxygen species (ROS) is thought to play a key role in the progression of diabetic nephropathy. Recent experimental studies have suggested that the receptor for advanced glycation end products (RAGE), which is central to the advanced glycation pathway, may mediate renal structural and functional damage via oxidative stress. This review focuses on how RAGE and subsequent ROS generation play a deleterious role in the diabetic kidney, promoting cross‐talk among signaling pathways, ultimately leading to renal dysfunction.