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Association Study of the Calcineurin A Gamma Subunit Gene (PPP3CC) and Methamphetamine‐Use Disorder in a Japanese Population
Author(s) -
Kinoshita Y.,
Ikeda M.,
Ujike H.,
Kitajima T.,
Yamanouchi Y.,
Aleksic B.,
Kishi T.,
Kawashima K.,
Ohkouchi T.,
Ozaki N.,
Inada T.,
Harano M.,
Komiyama T.,
Hori T.,
Yamada M.,
Sekine Y.,
Iyo M.,
Sora I.,
Iwata N.
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1432.021
Subject(s) - schizophrenia (object oriented programming) , single nucleotide polymorphism , haplotype , genetic association , psychosis , genetics , candidate gene , population , calcineurin , allele , medicine , biology , gene , psychiatry , genotype , environmental health , transplantation
Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case‐control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)‐induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH‐related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP‐use disorder in a Japanese population. We selected five haplotype‐tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP‐use disorder in the Japanese population.