Premium
Immune Response of Theileria sp.‐infected Sheep to Recombinant Theileria Proteins
Author(s) -
Seitzer Ulrike,
Liu Zhijie,
Yin Hong,
Beyer Doreen,
Kullmann Birgit,
Miranda Joana,
Ahmed Jabbar S.
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1428.080
Subject(s) - theileria , recombinant dna , immune system , biology , antibody , peripheral blood mononuclear cell , virology , humoral immunity , immunity , in vitro , immunology , gene , parasite hosting , biochemistry , world wide web , computer science
Sheep and goats in northwest China suffer from theileriosis from infection with Theileria sp. (China), resulting in large economic losses. To investigate the immune response to infection with Theileria sp. (China), parameters of cellular and humoral immunity of experimentally infected sheep against two recombinantly expressed Theileria proteins were investigated. The in vitro proliferative response of blood mononuclear cells to a recombinant T. annulata membrane protein and a recombinant Theileria sp. (China) homologue to T. annulata surface protein, both putative membrane proteins, was significantly elevated and significant amounts of specific immunoglobulins were produced against both.