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Attenuation of Colon Carcinoma Tumor Spread by Intravenous Immunoglobulin
Author(s) -
DAMIANOVICH MAYA,
SOLOMON ARIEH SORIN,
BLANK MIRI,
SHOENFELD YEHUDA
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1423.061
Subject(s) - in vivo , colorectal cancer , antibody , colon carcinoma , medicine , in vitro , carcinoma , cancer research , lewis lung carcinoma , lung , pathology , immunology , metastasis , cancer , chemistry , biology , biochemistry , microbiology and biotechnology
Abstract : The impact of IVIg on metastatic capacity of CT26 murine colon carcinoma cells was studied using in vitro and in vivo methods. IVIg inhibited CT26 cell proliferation and invasion through an extracellular matrix in a dose‐ and time‐dependent manner. Systemic treatment of mice with IVIg significantly inhibited metastatic potential of CT26 colon carcinoma cells observed as tumor nodules and lung weight reduction. Treating CT26 cell‐implanted rabbit corneas with IVIg led to shrinking and complete disappearance of tumor mass in 10 days. These results provide the evidence that IVIg may be considered as a supportive therapy for inhibition of colon carcinoma tumor spread .