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Autologous Stem Cell Transplantation for Severe Autoimmune Diseases
Author(s) -
GUALANDI F.,
BRUNO B.,
Van LINT M.T.,
LUCHETTI S.,
UCCELLI A.,
CAPELLO E.,
MANCARDI G.L.,
BACIGALUPO A.,
MARMONT A.
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1423.048
Subject(s) - medicine , hematopoietic stem cell transplantation , refractory (planetary science) , transplantation , adverse effect , multiple sclerosis , autologous stem cell transplantation , autoimmune disease , immunology , surgery , antibody , physics , astrobiology
: The first autologous hematopoietic stem cell transplantation in Europe for a patient with severe refractory systemic lupus erythematosus (SLE) was performed in Genoa in 1996. Since then, 32 patients with a wide spectrum of autoimmune diseases (ADs) received autologous transplants, 22 of them with multiple sclerosis (MS). There were no fatal adverse events. All patients had complete or very good partial remissions, but relapses were frequent, especially in SLE, though never as aggressive as pretransplant. The mechanism of action of this intervention remains not completely understood, as briefly discussed here.