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Scleroderma Renal Crisis, Still a Life‐Threatening Complication
Author(s) -
TEIXEIRA LUIS,
MAHR ALFRED,
BEREZNÉ ALICE,
NOËL LAUREHÉLÈNE,
GUILLEVIN LOÏC,
MOUTHON LUC
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1422.027
Subject(s) - medicine , complication , dialysis , scleroderma (fungus) , angiotensin converting enzyme , disease , intensive care medicine , pathology , blood pressure , inoculation
: Scleroderma renal crisis (SRC) is a major complication in patients with systemic sclerosis (SSc). SRC occurs during the first 4 years of disease evolution in more than 75% of the cases, almost exclusively in patients with diffuse SSc. Other risk factors, including preceding corticosteroid therapy, have been associated with an increased occurrence of SRC. Prior to the late 1970s, SRC was a major cause of death in SSc patients. However, the prognosis has dramatically improved with the introduction of angiotensin‐converting enzyme inhibitors. Thus, prompt diagnosis and early initiation of angiotensin‐converting enzyme inhibitors therapy will improve the outcome. Nevertheless, additional antihypertensive treatments are often needed. Quite a large proportion of patients require dialysis, although this therapy may be stopped in approximately one‐third of patients. Patients remaining on dialysis after 2 years can be proposed for a renal transplantation.