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Regulatory T Cells and Systemic Lupus Erythematosus
Author(s) -
PARIETTI VÉRONIQUE,
CHIFFLOT HÉLÈNE,
MULLER SYLVIANE,
MONNEAUX FANNY
Publication year - 2007
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1422.007
Subject(s) - immunology , peripheral tolerance , autoimmunity , il 2 receptor , immune system , regulatory b cells , immune tolerance , systemic lupus erythematosus , biology , regulatory t cell , t cell , medicine , interleukin 10 , disease , pathology
: Regulatory T cells, especially CD4 + CD25 + T cells, “natural killer” T cells and γδ T cells, are central in the maintenance of peripheral tolerance and the protection from the development of autoimmune diseases. Numerical or functional modifications of these cell populations were demonstrated to lead to the breakdown of tolerance and the emergence of autoimmunity. Involvement of regulatory T cells in the pathogenesis of systemic autoimmune diseases, such as systemic lupus erythematosus, might be of first importance. In murine models and patients with lupus, these regulatory T cells seem to be reduced in number. Functional deficiencies have also been described in a few studies. A better knowledge of regulatory T cell functional properties in systemic autoimmune diseases is essential to manipulate these cells and hopefully to restore immune tolerance.