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Multi‐Scale Model of O 2 Transport and Metabolism
Author(s) -
Zhou Haiying,
Lai Nicola,
Saidel Gerald M.,
Cabrera Marco E.
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1420.021
Subject(s) - oxygen transport , skeletal muscle , cellular respiration , oxygen , chemistry , respiration , oxidative phosphorylation , metabolism , biophysics , oxygenation , biochemistry , anatomy , biology , mitochondrion , ecology , organic chemistry
Regulation of pulmonary oxygen uptake (VO 2p ) during exercise depends on cellular energy demand, blood flow, ventilation, oxygen exchange across membranes, and oxygen utilization in the contracting skeletal muscle. In human and animal studies of metabolic processes that control cellular respiration in working skeletal muscle, pulmonary VO 2 dynamics is measured at the mouth using indirect calorimetry. To provide information on the dynamic balance between oxygen delivery and oxygen consumption at the microvascular level, muscle oxygenation is measured using near‐infrared spectroscopy. A multi‐scale computational model that links O 2 transport and cellular metabolism in the skeletal muscle was developed to relate the measurements and gain quantitative understanding of the regulation of VO 2 at the cellular, tissue, and whole‐body level. The model incorporates mechanisms of oxygen transport from the airway openings to the cell, as well as the phosphagenic and oxidative pathways of ATP synthesis in the muscle cells.