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The Sall2 Transcription Factor Is a Novel p75NTR Binding Protein That Promotes the Development and Function of Neurons
Author(s) -
Pincheira Roxana,
Donner David B.
Publication year - 2008
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1418.026
Subject(s) - tropomyosin receptor kinase a , low affinity nerve growth factor receptor , nerve growth factor , microbiology and biotechnology , transcription factor , neurotrophin , receptor , chemistry , biology , gene , biochemistry
Nerve growth factor (NGF) regulates the functions of neurons by binding the p75 neurotrophin receptor (p75NTR) and TrkA receptors. It is shown here that it has been found that the Sall2 transcription factor forms a complex with p75NTR. NGF dissociates Sall2 from p75NTR and also activates TrkA, which promotes translocation of Sall2 into the nucleus. Nuclear Sall2 activates target genes that modulate the growth and development of neurons. Thus, one way that p75NTR and TrkA can modulate the functions of neurons is by regulating the localization and actions of Sall2.